Mycobacterium bovis BCG vertebral osteomyelitis after intravesical BCG therapy, diagnosed by PCR-based genomic deletion analysis.
نویسندگان
چکیده
We report a case of Mycobacterium bovis BCG vertebral osteomyelitis 1.8 years after intravesical BCG therapy for bladder cancer. We differentiated BCG from other Mycobacterium tuberculosis complex members by PCR analysis of deletion regions and started an appropriate chemotherapy regimen resulting in the remission of symptoms within 1 month.
منابع مشابه
Mycobacterial Osteomyelitis of the Spine Following Intravesical BCG Therapy for Bladder Cancer
Osteomyelitis is an infection of the bone that can involve the vertebral column. A rare cause of vertebral osteomyelitis is Mycobacterium bovis after intravesical Bacillus Calmette-Guerin (BCG) therapy for transitional cell carcinoma of the bladder. In this report, we describe the case of a 64-year-old male presenting with constitutional symptoms, progressive thoracic kyphosis, and intractable ...
متن کاملMycobacterium bovis BCG causing vertebral osteomyelitis (Pott's disease) following intravesical BCG therapy.
We report a case of Mycobacterium bovis BCG vertebral osteomyelitis in a 79-year-old man 2.5 years after intravesical BCG therapy for bladder cancer. The recovered isolate resembled M. tuberculosis biochemically, but resistance to pyrazinamide (PZA) rendered that diagnosis suspect. High-pressure liquid chromatographic studies confirmed the diagnosis of M. bovis BCG infection. The patient was or...
متن کامل704Mycobacterium bovis vertebral osteomyelitis due to intravesical Bacillus Calmette-Guérin (BCG): A rare complication of a common therapy
Background. Intravesical Bacillus Calmette-Guérin (BCG) is a well known and effective therapy for bladder carcinoma. Complications from BCG are very uncommon. Vertebral osteomyelitis secondary to BCG is exceedingly rare. Methods. We report a case of vertebral osteomyelitis due to Mycobacterium bovis following intravesical BCG therapy. We then present a review of all the reported cases of BCG-in...
متن کاملMycobacterial Infection after Intravesical Bacillus Calmette-Guërin Treatment for Bladder Cancer: A Case Report
Bacillus Calmette-Guërin (BCG) has been traditionally used as a vaccine against tuberculosis. Further, intravesical administration of BCG has been shown to be effective in treating bladder cancer. Although BCG contains a live attenuated strain of Mycobacterium bovis, complications such as M. bovis BCG infection caused by BCG administration are extremely rare. Here, we report a case of BCG infec...
متن کاملChest wall abscess due to Mycobacterium bovis BCG after intravesical BCG therapy.
We report a case of chest wall abscess caused by Mycobacterium bovis BCG that arose as a complication 1 year after intravesical BCG instillation. We identified M. bovis BCG Tokyo 172 in the abscess by PCR-based typing of Mycobacterium tuberculosis complex and analysis of variable number of tandem repeats data.
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 45 12 شماره
صفحات -
تاریخ انتشار 2007